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McArdle News
Kenealy Receives First Robert C. Mierendorf Undergraduate Research Fellowship
Brian Kenealy has been awarded the first Robert C. Mierendorf, Jr. Undergraduate Research Fellowship at the McArdle Laboratory for Cancer Research. This Fellowship was established in 2006 by Dr. Mierendorf’s colleagues at Novagen (now called EMD Biosciences, Inc.), Madison, WI, in appreciation of Dr. Mierendorf’s outstanding leadership throughout his career there. Brian, a junior majoring in Molecular Biology, will carry out his research in Dr. Elaine Alarid’s laboratory. Brian’s project will focus on the role of DNA binding in the control of estrogen receptor protein stability in breast cancer.
A Milwaukee, WI native, Bob Mierendorf received a B.S. degree in Molecular Biology from UW-Madison in 1974. Fascinated by all aspects of science, Bob began his research career at the McArdle Laboratory for Cancer Research. He completed a PhD in Oncology under the direction of Dr. Gerald C. Mueller with his dissertation work on “Glucocorticoid Hormone Action in Friend Erythroleukemia Cells”. Bob then assumed the position of Director of Research and Development at Promega Corporation. In 1989, Bob founded, with Warren Kroeker and David Dubbell, a small biotechnology start-up company called Novagen, Inc., and served as Vice President and General Manager. Novagen was established as a wholly-owned subsidiary of Pel-Freez, Inc., and specialized in the production of custom gene libraries and specialty reagents. Novagen was the first company to commercialize the pET System (developed by Dr. F. William Studier and his colleagues at Brookhaven National Laboratory), and over the next several years became a leader in protein expression systems. In January 1998 Novagen was acquired by CN Biosciences (CNBI), and Bob was named President of Novagen. The following year CNBI was acquired by Merck KGaA, and in 2003 the company officially changed its name to EMD Biosciences, Inc. Bob served as Chief Technology Officer of CNBI and EMD Biosciences. Through these many transitions, Bob was instrumental in the growth and the success of the company and the people who work there.
Thanks to Dr. Mierendorf’s colleagues at EMD Biosciences, this Fellowship will be awarded annually to an outstanding undergraduate student who is carrying out research at the McArdle Laboratory for Cancer Research.
McArdle Welcomes New Students
Nine graduate students joined the McArdle Laboratory for Cancer Research beginning with the Spring 2002 semester. They are: Cellular and Molecular Biology majors Luis Acevedo (Farnham laboratory), Scott Balsitis (Lambert laboratory), Adam Feire (Compton laboratory), Sigrid Holmgren (Lambert laboratory), Larry Kwong (Dove laboratory), Heather Scobie (Young laboratory), and Sara Speros (Alexander laboratory), and Genetics majors Jennifer Dingwall (Burgess laboratory) and Stephanie Nelson (Gould laboratory). They join Oncology students Young-chul Kim (Alexander laboratory), Sang Kyun Lim (Hoffmann laboratory), Scott Lindner (Sugden laboratory), and Linh Nguyen (Bradfield laboratory) to make up the 1st -year McArdle graduate student class. Steve Knight and Bryan Zhao, both in the Hoffmann laboratory, recently transferred to McArdle from other laboratories. Please welcome these new students.
Chen Awarded CRFA Fellowship
Dr. Xiaodi Chen, a postdoctoral research associate in the laboratory of Dr. William F. Dove, has been awarded a fellowship from the Cancer Research Foundation of America (CRFA). The 2-year fellowship will help to support Dr. Chen's research efforts to identify biomarkers for human colorectal cancer and to develop effective methods to detect the early tumors. Dr. Chen's research involves an active collaboration between Dr. Dove's cancer genetics laboratory and the virology laboratory of Dr. John A.T. Young in the McArdle Laboratory for Cancer Research.
Colorectal cancer is the third most common cancer and causes the second most cancer deaths in the United States. This cancer can be completely cured by surgery if it is discovered in its early stages. Therefore, early detection is critical for the reduction of colorectal cancer death. Currently in advanced parts of the world, people with a high risk of colorectal cancer are recommended to have regular tests to detect early colorectal cancers. However, the current tests for early detection are inaccurate, expensive or unacceptable by the general public. With several new approaches using mutant mice that develop intestinal tumors, Dr. Chen aims to find genes that produce tumor-associated products. These genes and their products will be explored as "biomarkers" for the detection of early tumors. Sensitive methods to detect these tumor biomarkers in serum and stool samples will first be explored in mice. The biomarkers that can be sensitively detected in the mouse will be used to investigate the corresponding human biomarkers. This project, if successful, aims to develop prompt and economical methods broadly acceptable by the public, to accurately screen for early colorectal tumors in the high-risk population and, eventually, the general population.
Dr. Chen, who began his work at the McArdle Laboratory last year, received his Ph.D. degree from the University of Missouri-Columbia. The CRFA is a non-profit health foundation, located in Alexandria, VA, whose mission is "the prevention of cancer through scientific research and education".
Nobel Laureate Günter Blobel Visits UW-Madison
by Jennifer Michalowski
Dr. Günter Blobel, 1999 Nobel Laureate for Physiology or Medicine, visited the University of Wisconsin-Madison campus recently to speak about his research on protein targeting.
Dr. Blobel, professor at Rockefeller University, was awarded the Nobel Prize for his discovery that "proteins have intrinsic signals that govern their transport and localization in the cell." In addition to identifying these signals, he has characterized the mechanisms whereby they direct a cell's proteins to the correct compartments and enable their transport across membranes.
Building on his studies on the localization of proteins to the endoplasmic reticulum, Blobel found in 1980 that basic principles governed the trafficking of proteins to other organelles as well. Newly synthesized proteins are equipped with short sequences of amino acids that act as "address tags". These signal sequences direct proteins to the correct compartment, where they are recognized by binding proteins that facilitate passage through a channel in the organelle's membrane.
Dr. Blobel earned a Ph.D. in Oncology at the McArdle Laboratory for Cancer Research, where he worked with Professor Van R. Potter on the distribution of ribosomes within cells. Professor Potter remembers Blobel as an independent student who required little guidance. He described Dr. Blobel's approach to scientific questions as beginning with "a speculative metaphor in advance of any experimental evidence." Indeed, Dr. Blobel described the 1971 model in which he first postulated that signal sequences directed proteins to their appropriate destinations as "a wild scheme for which there was absolutely no evidence."
"The genius of the man," Potter commented, "is to say 'how can I test this?' He is just about without equal on that end."
Despite the tremendous strides Dr. Blobel has made in uncovering the mysteries of protein targeting, he remains humbled by how little we know. "I think most of the questions are left," he said. "What is left to be done is humongous."
While visiting the Madison campus, Dr. Blobel also presented a talk on reconstruction efforts in Dresden, Germany, a once-prominent cultural center destroyed during World War II. Fifty years after witnessing its bombing, Dr. Blobel founded the Friends of Dresden organization to support Dresden's restoration. He has donated most of his Nobel Prize money to that cause.
Ahlquist and Gould awarded WARF Named Professorships
Drs. Paul Ahlquist and Michael N. Gould have been selected to receive WARF Named Professorships in honor of their significant research contributions, as well as their contributions to teaching and service. Effective July 1, 2000, Dr. Ahlquist will be the Paul J. Kaesberg Professor of Plant Pathology, Molecular Virology, and Oncology, and Dr. Gould will be the Kelly H. Clifton Professor. Both Drs. Kaesberg and Clifton are professor emeritus at the University of Wisconsin-Madison and were leaders in their fields.
Bradfield receives the SOT Achievement Award
Dr. Christopher A. Bradfield recently received the 2000 Achievement Award from the Society of Toxicology. The Achievement Award is given to an investigator who is within 15 years of receiving the doctorate degree and who has made ground-breaking research contributions in the area of toxicology.
Dove elected to the American Academy of Arts and Sciences
Dr. William F. Dove has been elected as a Fellow of the American Academy of Arts and Sciences. The Academy "honors leading intellectuals from both this country and abroad in every field and profession." Dr. Dove's election to the Academy recognizes his distinguished contributions to his profession. Newly elected members will be formally inducted into the Academy at a ceremony to be held at the House of the Academy in Cambridge, MA, in October 2000.
Four receive Hilldale Undergraduate/Faculty Research Awards
Heather Barnes (Lambert laboratory), Angela Speer (Hoffmann laboratory), Jesse Waggoner (Dove laboratory), and Kathleen Worringer (Sugden laboratory) have been selected to receive 2000-2001 Wisconsin/Hilldale Undergraduate/Faculty Research Awards to carry out research projects at the McArdle Laboratory for Cancer Research. The students were judged on the basis of the originality and intellectual significance of their research proposals. The Awards provide a grant to the student and funds to the faculty supervisor to help defray the costs of research.
Alumni News
AARC Alumni Gathering
The annual McArdle alumni gathering at the 2003 Meeting of the American Association for Cancer Research will be held on Saturday, July 12, 2003, from 6:30 p.m. to 8:30 p.m., in Congressional Hall A at the Renaissance Hotel, 999 9th Street NW, Washington, D.C. Alumni and their guests are welcome.
Bernstein Joins PLOS
McArdle alumnus Philip Bernstein has joined the Public Library of Science (PLOS) as a Senior Editor. PLOS is a "nonprofit organization of scientists committed to making the world's scientific and medical literature a public resource." Previously Philip was the executive editor of the Journal of Experimental Medicine. Philip received his Ph.D. in oncology under the direction of Dr. Jeff Ross. For additional information about PLOS, go to http://www.plos.org
AARC Alumni Gathering
The annual McArdle alumni gathering at the 2002 Meeting of the American Association for Cancer Research will be held on Sunday, April 7, from 6:30 p.m. to 8:30 p.m., in the Club Room of the San Francisco Marriott. Alumni and their guests are welcome.
Conney to Give AACR-DeWitt Goodman Memorial Lecture
Dr. Allan Conney, Rutgers-State University of New Jersey, will present the 7th AACR-DeWitt S. Goodman Memorial Lecture on April 10 at the annual AACR Meeting in San Francisco. Dr. Conney is being honored for his outstanding contributions in the field of drug metabolism. Dr. Conney received his Ph.D. degree at the McArdle Laboratory under the direction of Drs. James and Elizabeth Miller.
Chet Elected President of Weizmann Institute of Science
The Board of Governors of the Weizmann Institute of Science, Rehovot, Israel, has elected Professor Ilan Chet as President of the Institute. Dr. Chet assumed his responsibilities in December 2001, succeeding Professor Haim Harari. Dr. Chet completed his doctoral research in microbiology at the Hebrew University of Jerusalem in Rehovot and carried out postdoctoral studies at the McArdle Laboratory with Dr. Harold P. Rusch from 1968-1970. Dr. Chet has been the recipient of numerous prizes and awards in recognition of his research accomplishments. The Weizmann Institute of Science has ~2,500 scientists, students, and support staff working on research projects that cover a broad spectrum of contemporary science.
McArdle alumnus Blobel wins 1999 Nobel Prize
Dr. Günter Blobel was awarded the 1999 Nobel Prize in Physiology or Medicine "for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell". Dr. Blobel is the John D. Rockefeller Jr. Professor at Rockefeller University and a Howard Hughes Medical Institute Investigator. Dr. Blobel received a medical degree from the University of Tübingen, Germany. He received a Ph.D. in Oncology from the University of Wisconsin-Madison where he worked with Dr. Van R. Potter in the McArdle Laboratory for Cancer Research. Dr. Blobel is donating his Nobel Prize money to the Friends of Dresden to help rebuild Frauenkirche (the Church of Our Lady), which was bombed during WWII.
Rohrschneider receives Guggenheim Foundation Fellowship
Dr. Larry Rohrschneider, Basic Sciences Division, Fred Hutchinson Cancer Research Center and affiliate Professor of Pathology at the University of Washington, has been selected to receive a John Guggenheim Memorial Foundation Fellowship Award. The Fellowships are awarded individuals who have already demonstrated "exceptional capacity for productive scholarship". The purpose of the Guggenheim Fellowship program is to provide unrestricted funds to encourage as much creative freedom as possible. The Fellowship will allow Dr. Rohrschneider "to collaborate with researchers at the Claude Bernard University in France on molecular mechanisms for regulating the growth of blood cells." Dr. Rohrschneider received a Ph.D. in Oncology, under the direction of Dr. Roswell K. Boutwell, at the McArdle Laboratory for Cancer Research. The focus of Dr. Rohrschneider's Ph.D. research was phospholipid metabolism and the involvement of membranes in tumor promotion in mouse skin.